CO2 capture and geologic storage (CCGS) is regarded as an effective strategy for reduction of anthropogenic carbon release and mitigation of global warming. Typical methodologies and theories regarding CCGS laboratory investigation are reviewed. The coupled physical-geochemical processes in relation to four mechanisms of CO2 geologic sequestration are introduced. Findings from core flood experiments such as relationship between CO2 saturation and permeability are included. Multiphase flow apparatus with procedures for laboratory investigation are introduced. A collection of methodologies (equations) for calculation of CCGS-related physical parameters are presented, followed by a brief introduction of petrophysical characterization and geochemical tests. Problems or research opportunities are discussed regarding the current CCGS laboratory work. The paper ends up with suggestion remarks.